Tetramethylammonium does not universally neutralize sequence dependent DNA stability

Tetramethylammonium does not universally neutralize sequence dependent DNA stability.

Effects of different concentrations of Tetramethylammonium on the thermostability of six DNA dumbbells with similar well defined sequences have been investigated. Each molecule has a 16 base pair duplex stem linked on both ends by T4 single strand loops. Only the sequence of the four central base pairs distinguishes one molecule from the next. The distinguishing central sequences are, [A-T-A-T]...

Sequence Dependent Elasticity of DNA

The DNA contained in every living cell not only stores the genetic information; it functions in a complex molecular network that can condense, transcribe, replicate and repair genes. The essential role played by the sequence dependent structure and deformability of DNA in these basic processes of life, has received increasing attention over the past years. The present work aims at better unders...

Sleep does not enhance motor sequence learning.

Improvements in motor sequence performance have been observed after a delay involving sleep. This finding has been taken as evidence for an active sleep consolidation process that enhances subsequent performance. In a review of this literature, however, the authors observed 4 aspects of data analyses and experimental design that could lead to improved performance on the test in the absence of a...

Glide Formation in Kinande Does Not Neutralize an Underlying [ATR] Contrast

Unlike most other modern Bantu languages, Kinande has faithfully preserved the Proto-Bantu contrast between [-ATR] and [+ATR] high vowels (Hyman, 2002). As a result, while other Bantu languages typically have only two contrastive high vowels (i.e. high back and high front), Kinande has four: [-ATR] [i u] and [+ATR] i u ]. 1 These four high vowels, together with mid [e o] and low [a], are laid o...

DNA sequence mediates nucleosome structure and stability.